M. Garcia
Spain
Research Article
Angiotensin Converting Enzyme Gene Polymorphism as a Genetic Biomarker of Diabetic Peripheral Neuropathy: Longitudinal Prospective Study
Author(s): J. Jurado, J. Ybarra, J.H. Romeo, M. Garcia and E. Zabaleta-del-OlmoJ. Jurado, J. Ybarra, J.H. Romeo, M. Garcia and E. Zabaleta-del-Olmo
Background: Identifying patients at risk of developing diabetic peripheral neuropathy (DPN) is of paramount importance in those with type 2 diabetes mellitus (T2DM) to provide and anticipate secondary prevention measures as well as intensify action on risk factors, particularly so in primary care. Noteworthy, the incidence of DPN remains unknown in our environment. Aims: i) to analyze Angiotensin Converting Enzyme (ACE) gene polymorphisms as a genetic marker of risk of developing DPN, ii) to determine the incidence of DPN in our environment. Research design and methods: Longitudinal prospective cohort study with three years of follow-up involving a group of T2DM (N=283) randomly selected. ACE gene polymorphisms distribution (I=insertion; D=deletion) was determined. DPN was diagnosed using clinical and neurophysiology evaluation. Results: Baseline DPN prevalence was 28.97% (CI95%.. View More»
