Li-cai Zhang
Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College,
Xuzhou 221002
Indiana
Research Article
Distribution of TRPV1 in CSF Contacting Nucleus of Rat Brain Parenchyma and its expression in Neuropathic Pain
Author(s): Chun- Xu, Zi-jun Zhao, Ting-ting Wu and Li-cai ZhangChun- Xu, Zi-jun Zhao, Ting-ting Wu and Li-cai Zhang
Background: The cerebrospinal fluid-contacting nucleus (CSF-CN), distributes and localizes in the ventral periaqueductal central gray (PAG) of the brainstem, which may influence actual composition of the cerebrospinal fluid (CSF) for non-synaptic signal transmission via releasing or absorbing bioactive substance. TRPV1 has been found in both the peripheral and spinal within centres known for their role in pain detection, transmission and regulation, consistent with its role in pain. Therefore, it is speculated that the CSF-CN participate in pain modulation via the receptor TRPV1. The present study aimed to observe the TRPV1 expression and distribution in the CSF-CN of rat brain parenchyma, and to explore the effects of TRPV1 on the CSF-CN in neuropathic pain.
Methods: The model of neuropathic pain with chronic constri.. View More»
