Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Kai Yang

Kai Yang


  • Special Issue Article
    Metabolic Control of Th17 Cell Generation and CNS Inflammation
    Author(s): Kai Yang and Hongbo ChiKai Yang and Hongbo Chi

    Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), results from uncontrolled auto reactive T cells that infiltrate the CNS and attack the myelin sheath. Th17 cells play a prominent role in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Extensive studies have focused on understanding the roles of cytokine signaling and transcriptional network in the differentiation of Th17 cells and their pathogenicity in CNS inflammation. Aside from these events, activated T cells dynamically reprogram their metabolic pathways to fulfill the bioenergic and biosynthetic requirements for proper T cell functions. Emerging evidence indicates that modulation of these metabolic pathways impinges upon the differentiation of Th17 cells and the pathogenesis of EAE... View More»

    DOI: 10.4172/2155-9562.S12-004

    Abstract PDF

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