Janine Andrade Moscona
Brazil
Research Article
Dorsolateral Prefrontal Cortex Activity and Neuromodulation in Crack-Cocaine Dependents during Early Abstinence
Author(s): Catarine Lima Contia, Janine Andrade Moscona, Ester Miyuki and Nakamura-PalaciosaCatarine Lima Contia, Janine Andrade Moscona, Ester Miyuki and Nakamura-Palaciosa
Rationale: It is broadly known that addicted subjects have frontal dysfunction which is translated into: 1) low frontal activity in areas related to executive functions involved in the control over drug use; and 2) high frontal activity in areas related to incentive salience involved in the craving for drug use.
Method: Electrical activity was correlated with days of abstinence and then sham-controlled session of transcranial direct current stimulation (tDCS) was performed in crack-cocaine users up to one month of abstinence. They were randomly divided to receive left cathodal/right anodal tDCS (20 min, 2 mA, 35 cm2) or sham procedure over the dorsolateral prefrontal cortex (DLPFC).
Results: Absolute values from low-resolution brain electromagnetic tomography (LORETA) indicated that the activity in both left and right DL.. View More»
