Ikuo Homma
Japan
Research Article
Inter- and Intra-Hemispheric Fibers of Olfactory and Motor Areas in
Kallmann Syndrome with Defective Corpus Callosum
Author(s): Yuri Masaoka, Andrew Zalesky, Masaru Tatsuno, Shingo Okamoto, Masaki Yoshida, Nobuyoshi Koiwa, Mutsutaka Kobayakawa, Keiko Watanabe, Masahiro Ida, Ikuo Homma, Masahiko Izumizaki and Christos PantelisYuri Masaoka, Andrew Zalesky, Masaru Tatsuno, Shingo Okamoto, Masaki Yoshida, Nobuyoshi Koiwa, Mutsutaka Kobayakawa, Keiko Watanabe, Masahiro Ida, Ikuo Homma, Masahiko Izumizaki and Christos Pantelis
Kallmann syndrome (KS) is a form of hypogonadotropic hypogonadism with variable disturbances of olfaction, with some patients having complete anosmia. In this study, we report observations of cerebral white matter connectivity in a rare patient diagnosed with KS associated with a defective corpus callosum (DCC) (KS-DCC) using non-invasive tractography-based diffusion tensor imaging (DTI). In the partial CC, two genua remnants were observed. The KS-DCC patient had a normal life without cognitive impairment and had a normal intelligence quotient, manifesting only the two common symptoms hypogonadotropic hypogonadism and anosmia. Mirror movements were not observed. Compared with normal, DTI tractography of the olfactory related area in the KS-DCC patient revealed fewer inter-hemispheric fibers between right and left olfactory areas (including olfactory tubercle and anterior commissure). .. View More»
