Horeya E Korayem
Egypt
Research Article
Potential Therapeutic Effect of Hematopoietic Stem Cells on Cerebellar Ataxia in Adult Female Rats Subjected to Cerebellar Damage by Monosodium Glutamate
Author(s): Horeya E Korayem, Mohamed Abdo, Magda M Naim, Soha E Yones and Somaya HosnyHoreya E Korayem, Mohamed Abdo, Magda M Naim, Soha E Yones and Somaya Hosny
Background: Research evidence has indicated that monosodium glutamate (MSG) consumption produces
certain deleterious effects on the cerebellum of adult rats at high doses which can consequently affect cerebellar
function. The use of stem cells in nervous system disorders is a growing field, which in numerous reports has shown
promising results in the restoration of neurological function.
Aim: To compare the effect of injection of human umbilical cord blood CD34+ stem cells versus CD34- fraction in
a rat model of cerebellar damage induced by monosodium glutamate.
Methods: Forty adult female albino rats were equally randomized into 4 groups: group I served as control,
group II received MSG, group III received MSG followed by CD34+ stem cell separated from umbilical cord blood
of human male fetuses, group IV received MSG followed by.. View More»
