Hermann Reichenspurner
Germany
Case Report
Cardiogenic Shock 14 Years Post Anthracyclines
Author(s): Stephanie Schmidt, Nils H Thoennissen, Meike Rybczynski, Florian M Wagner, Ulrich M Gross, Tobias Deuse, Stefan Blankenberg, Hermann Reichenspurner and Markus J BartenStephanie Schmidt, Nils H Thoennissen, Meike Rybczynski, Florian M Wagner, Ulrich M Gross, Tobias Deuse, Stefan Blankenberg, Hermann Reichenspurner and Markus J Barten
Significant advances in cancer treatment markedly improved survival rates of children diagnosed with cancer. However, chemotherapeutic or radiologic treatments might result in health consequences. For example, anthracycline agents were one of the most widely used chemotherapeutic drugs and known to cause cardiotoxicity.
We report on a 20-year old man with sudden onset of multi-organ-failure caused by a severe cardiogenic shock and the urgent need for implantation of a continuous-flow left ventricular assist device. Fourteen years before, he was diagnosed with childhood T-lymphocyte acute lymphoblastic leukaemia implying the application of the ALL-BFM-2000- protocol with a cumulative dose of 240 mg/m2 of anthracycline (120 mg/m2 daunorubicin + 120 mg/m2 doxorubicin). Postchemotherapeutic clinical monitoring lasted for two years till complete rem.. View More»