Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?
Author(s): Zahra Soltani, Mohammad Khaksari, Sedigheh Amiresmaili, Vida Naderi, Elham Jafari and Nader ShahrokhiZahra Soltani, Mohammad Khaksari, Sedigheh Amiresmaili, Vida Naderi, Elham Jafari and Nader Shahrokhi
Our previous studies have demonstrated that estrogen is protective in traumatic brain injury (TBI). However, concerns about negative consequences of estrogen therapy have led to find other strategies to obtain estrogen’s benefits in the brain, including the use of a soy diet. This study was designed to determine whether a soy diet is protective in TBI. The male Albino N-Mary rats received either a soy- free diet (SFD) or soy diet (SD) from weaning to adulthood. The SFD and SD rats were separately divided to two groups of sham and TBI (n= 18 in each group). The diffuse and severe brain injury was induced by Marmarou method. The disruption of Blood brain- barrier (BBB) was evaluated 48 h post- TBI. The intracranial pressure (ICP), the neurologic outcome, and the beam-walk task (WB) were determined before trauma, on trauma day (D0), .. Read More»