Dinesh G Nair
Department of Neurology, Massachusetts General Hospital,
15 Parkman St., Boston MA 02114-3117
Tanzania
Clinical image
Trigeminal Sensory Neuropathy in Mixed Connective Tissue Disease
Author(s): Sharika Rajan, Rajesh Gupta, Maria J Borja, Naina Rastalksy, Nagagopal Venna and Dinesh G NairSharika Rajan, Rajesh Gupta, Maria J Borja, Naina Rastalksy, Nagagopal Venna and Dinesh G Nair
A 23 year old woman presented to the clinic with Raynaud's phenomenon and numbness and tingling in her right cheek, chin and the right side of her tongue. Examination showed altered facial sensation to touch and pinprick in the right V1-V3 distributions. When investigations revealed that her ANA was 1:5120 in a speckled pattern and anti- RNP was 243.79 U, a diagnosis of Mixed Connective Tissue Disease (MCTD) was made. MRI brain showed diffuse enhancement of the Trigeminal nerves bilaterally, right>left. Trigeminal sensory neuropathy is the most common CNS manifestation of MCTD and often the presenting symptom. Prognosis is variable, some features respond to glucocorticoids.
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