Deepa
India
Review Article
Role of Platelets in Glutamate Mediated Excitotoxicity: An Overview
Author(s): Deepa, Arundhati Tiwari, Rameshwar Nath Chaurasia and Debabrata DashDeepa, Arundhati Tiwari, Rameshwar Nath Chaurasia and Debabrata Dash
Glutamate, the main excitatory neurotransmitter in central nervous system (CNS), binds primarily to two types of
receptors on the post-synaptic membrane of neuronal cells, namely metabotropic receptors and ionotropic
receptors. Metabotropic receptors are G-protein coupled receptors while ionotropic receptors are non-selective
ligand-gated ion channels, which allow movement of cations like Na+, K+ and Ca2+. The three most studied ionic
receptors are N-methyl-D-aspartate receptor (NMDAR), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
receptor (AMPAR), and Kainate receptor.
Glutamate synapse plays a pivotal role in many neurodegenerative disorders like Huntington disease, trauma,
epilepsy, Alzheimer and Amyotrophic lateral sclerosis, and cerebral ischemia. Understanding the mechanism of
these glutamate ligand-gated ion .. View More»
