Claudio Arra
Italy
Review Article
Organo-Metallic Compounds: Novel Molecules in Cancer Therapy
Author(s): Giuseppe Palma, Massimiliano DâAiuto, Domenica Rea, Sabrina Bimonte, Rosamaria Lappano, Maria Stefania Sinicropi, Marcello Maggiolini, Pasquale Longo, Claudio Arra and Carmela SaturninoGiuseppe Palma, Massimiliano D’Aiuto, Domenica Rea, Sabrina Bimonte, Rosamaria Lappano, Maria Stefania Sinicropi, Marcello Maggiolini, Pasquale Longo, Claudio Arra and Carmela Saturnino
The discovery of cis-platin in the treatment of cancer there has been a considerable exploration on the antitumoral activity of other transition metal complexes. One of the main problems about the application of transition metal complexes for chemotherapy is their potential toxicity. Recently the attention has been focused on titanium based complexes, which could have significant potential effect against solid tumor. The advantage of Ti (IV) complexes is their relative biological compatibility, which mostly leads to mild and revisable side effects. However, the hydrolytic instability of known Ti(IV) complexes and formation of different species upon water addition makes their therapeutic application problematic, and raises a strong interest in the development of relatively stable Ti(IV) complexes with well defined hydrolytic behavior that demonstrate appreciable cytotoxic activity. Str.. View More»
