Short-Term Memory Impairment Sparing the Central Executive in Relapsing-Remitting Multiple Sclerosis?
Author(s): Ehrlé Nathalie, Omigie Diana, Saenz Amaya, Debouverie Marc, Rumbach Lucien, Chaunu Marie-Pierre and Bakchine SergeEhrlé Nathalie, Omigie Diana, Saenz Amaya, Debouverie Marc, Rumbach Lucien, Chaunu Marie-Pierre and Bakchine Serge
Objective: It is widely accepted that working memory (WM) impairment has a high incidence in multiple sclerosis (MS). However, this WM impairment has rarely been analyzed with reference to a cognitive model. The aim of the study was to determine whether dysfunction in MS is due to WM or short-term memory deficits. Methods: We assessed the components of Baddeley's WM cognitive model, which include the phonological loop, visual sketch and central executive. Seventeen conditions implicating short term memory and executive functions (flexibility, inhibition, manipulation) were carried out by128MS patients diagnosed with RRMS, and 30 age matched healthy controls. Also assessed were three tasks of motor speed namely the Overt articulation rate, Digit-symbol copy test and Digit-symbol coding test. Results: In all but three conditions, t.. Read More»