Catarine Lima Contia
Programa de Pós-Graduação em Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo,
Av. Marechal Campos, 1468, 29.047 105 Vitória, ES
Brazil
Research Article
Dorsolateral Prefrontal Cortex Activity and Neuromodulation in Crack-Cocaine Dependents during Early Abstinence
Author(s): Catarine Lima Contia, Janine Andrade Moscona, Ester Miyuki and Nakamura-PalaciosaCatarine Lima Contia, Janine Andrade Moscona, Ester Miyuki and Nakamura-Palaciosa
Rationale: It is broadly known that addicted subjects have frontal dysfunction which is translated into: 1) low frontal activity in areas related to executive functions involved in the control over drug use; and 2) high frontal activity in areas related to incentive salience involved in the craving for drug use.
Method: Electrical activity was correlated with days of abstinence and then sham-controlled session of transcranial direct current stimulation (tDCS) was performed in crack-cocaine users up to one month of abstinence. They were randomly divided to receive left cathodal/right anodal tDCS (20 min, 2 mA, 35 cm2) or sham procedure over the dorsolateral prefrontal cortex (DLPFC).
Results: Absolute values from low-resolution brain electromagnetic tomography (LORETA) indicated that the activity in both left and right DL.. View More»
