Carolee J. Winstein
Tanzania
Research Article
Effects of Different Doses of Low Frequency rTMS on Motor Corticospinal Excitability
Author(s): Shailesh S. Kantak, Beth E. Fisher, Katherine J. Sullivan and Carolee J. WinsteinShailesh S. Kantak, Beth E. Fisher, Katherine J. Sullivan and Carolee J. Winstein
Low frequency (1Hz) repetitive transcranial magnetic simulation (TMS) is known to reduce motor corticospinal excitability. The purpose of this study was to systematically investigate the effects of different intensities and durations of LF-rTMS on measures of motor cortical excitability and inhibition, while trying to minimize sources of variability that affect corticospinal excitability. 9 non-disabled young adults were recruited and screened for contraindications to TMS. We employed a repeated measures design to investigate the effect of the following four intensity-duration combinations (doses) on motor corticospinal excitability: 1) subthreshold intensity (90%Resting Motor Threshold (RMT)) for 10 minutes, 2) subthreshold intensity (90%RMT) for 20 minutes, 3) suprathreshold intensity (110%RMT) for 10 minutes and 4) suprathreshold intensity (110%RMT) for 20 minutes. Each rTMS dose w.. View More»
