Bryan A Cotton
Professor of Surgery, Department of Surgery and the Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX,
Tanzania
Research Article
Hypocoagulability in Traumatic Brain Injury as Measured by Traditional Means and Thrombelastography
Author(s): Sherry L Sixta, Jessica C Cardenas, Ryan Kitagawa, Charles E Wade, John B Holcomb and Bryan A CottonSherry L Sixta, Jessica C Cardenas, Ryan Kitagawa, Charles E Wade, John B Holcomb and Bryan A Cotton
Background: Conflicting data exist regarding the association of traumatic brain injury (TBI) with coagulopathy as measured by conventional coagulation testing (CCT).
Objective: This study is intended to determine the prevalence of coagulopathy in TBI patients by CCT and rapid thrombelastography (r-TEG) and to determine the relationship between these laboratory tests and mortality.
Methods: Over an 18-month period, the admission r-TEG values (ACT, R-value, k-time, alpha, mA, and LY30) and CCTs (aPTT, INR, platelet count, and fibrinogen) were recorded on the highest-level trauma activations admitted directly from the injury scene. Patients were then categorized as non-TBI (Head AIS 0-2) or isolated TBI (Head AIS >2 and all other AIS scores ≤ 2), and all other patients were excluded. A patient has determined to have a coagulopathy if one or more of the following was.. View More»
