Barbara Depczynski
Australia
Mini Review
Sight Threatening Thyroid Eye Disease Complicating Hashimoto’s Thyroiditis
Author(s): Tamara K Young, Barbara Depczynski, Jack Wall, Hooshang Lahooti and Geoffrey WilcsekTamara K Young, Barbara Depczynski, Jack Wall, Hooshang Lahooti and Geoffrey Wilcsek
A case of sight threatening thyroid eye disease (TED), arising in a 55 year old woman with primary hypothyroidism due to Hashimoto’s thyroiditis (HT), is described. TSH receptor antibody (TSHRab) was positive as were orbital antibodies. Initial management consisted of methylprednisone intravenously followed by prednisone orally in a tapering dose, orbital irradiation and decompressive surgery. Visual acuity improved but 9 months later, there was evidence of relapse with features of compressive optic neuropathy, and exophthalmos had worsened. Prednisone dose was increased. At that time, TSHRab was negative. She underwent total thyroidectomy on the understanding that this was experimental therapy, surgery confirmed that thyroid pathology was solely TH without any evidence of Graves’ disease. Prednisone was successively tapered without further relapse. Rehabilitative ocular m.. View More»
