Arnal Carmen
Spain
Research Article
Prospective, Longitudinal, Multicenter Observational Study of Long-term Treatment with Intramuscular Interferon β-1a of Patients with Clinically Isolated Syndrome at High Risk of Conversion
Author(s): Hernández Miguel Ángel, Prieto, José María, Arnal Carmen, Sánchez Fernando and Izquierdo GuillermoHernández Miguel Ángel, Prieto, José María, Arnal Carmen, Sánchez Fernando and Izquierdo Guillermo
Introduction: Early initiation of treatment with intramuscular (IM) interferon (IFN) β-1a in patients with a single
demyelinating event suggestive of multiple sclerosis (MS) has been shown to reduce the risk of a second event.
This study investigated the characteristics of patients with clinically isolated syndrome (CIS), conversion to clinically
definite MS and quality of life (QoL) in clinical practice.
Methods: Patients eligible for IM IFNβ-1a for CIS were followed for 4 years (1 visit every 6 months, 9 visits in
total). Disease progression was assessed using the Expanded Disability Status Scale (EDSS). The rate of conversion,
adverse events and laboratory parameters were reported. Patients were administered QoL questionnaires (Functional
Assessment of Multiple Sclerosis [FAMS] and EuroQol 5D [EQ-5D]).
Results: Thirt.. View More»
