Journal of Multiple Sclerosis

ISSN - 2376-0389
NLM - 101654564

Andrea M Humm

Andrea M Humm


  • Review Article
    The Triple Stimulation Technique: An Advanced Neurophysiological Method to Assess Motor Function in Multiple Sclerosis
    Author(s): Michel R Magistris and Andrea M HummMichel R Magistris and Andrea M Humm

    The triple stimulation technique (TST) is a collision method enabling study of motor conduction within the central nervous system. By combining transcranial magnetic stimulation of the cortex to peripheral nerve stimulation, this method markedly improves the evaluation of the corticospinal pathways. In multiple sclerosis (MS) and other disorders affecting central motor conduction, it allows accurate detection and quantification of the proportion of normally conducting axons and of motor conduction failures caused by conduction block, neuronal or axonal lesions. This review aims to (1) describe briefly the TST, its yield, strengths and limitations, (2) summarize the observations made in MS to date, (3) discuss the potential of the method. The TST is non-invasive and safe. Its practicability has been optimized by use of efficient software. Several studies have demonstrat.. View More»

    DOI: 10.4172/2376-0389.1000188

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