Ahmad Almudhafer
Iraq
Research Article
Effect of Vildagliptin on Atherosclerosis Progression in High Cholesterol –Fed Male Rabbits
Author(s): Najah R Hadi, Hussain Abdulkadhim, Ahmad Almudhafer and Sahar A MajeedNajah R Hadi, Hussain Abdulkadhim, Ahmad Almudhafer and Sahar A Majeed
Background: Atherosclerosis is a progressive disease of large and medium-sized arteries characterized by the accumulation of lipids and fibrous elements in the large arteries. Aim of the study: This study was undertaken to assess the effect of vildagliptin on the progression of atherosclerosis via interfering with inflammatory and oxidative pathways.
Materials and Methods: 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups (6 rabbits for each group): Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed 1% cholesterol enriched diet for 12 weeks. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol-enriched diet and treated with vildaglipin 50 mg/kg/day orally for the next 6 weeks. Blood samples were collected at.. View More»
