Research - (2012) Volume 3, Issue 4
Splitted tablets provide dose flexibility, ease of swallowing and may reduce the costs of medication. Factors influencing the performance of splitting are shape, size, curvature and thickness of the tablet and the form and deepness of the score line. The uniformity of mass of divided tablets and loss of mass was calculated. It was observed that a notable amount of weight was loss and a wide verity was observed in fractioned tablets which were extended more than 2%. It is much higher than the pharmacopoeial limit which was not more than 1%.The weight uniformity and content uniformity test were performed to observe the variation of weight uniformity and content uniformity and it was observed that weight loss was more in splitting by hand than splitting by knife. 30% weight variation was observed between two half of the tablets. Drug content variation in half-tablets appeared to be attributable primarily to weight variation occurring when tablets powder or fragment during the splitting process.
