Sclerosing Polycystic Adenosis/Adenoma-Changing Paradigm: A | 85666

Medical Reports & Case Studies

ISSN - 2572-5130


Sclerosing Polycystic Adenosis/Adenoma-Changing Paradigm: A Mini Review

Reshma Venugopal*, Radhika Manoj Bavle, Sudhakara Muniswamappa and Soumya Makarla

Sclerosing polycystic adenosis or adenoma- the term is open for discussion. The lesion is termed sclerosing polycystic adenosis-a pseudo neoplastic reactive inflammatory process that appears similar to sclerosing adenosis of the breast- in the recent WHO 2017 salivary gland tumour classification. It is categorised under other epithelial lesions as sclerosing polycystic adenosis and considers sclerosing polycystic adenoma as a synonym. The evidence to state the lesion to be a neoplastic process rather than reactive is on the rise and consideration should be given based on the degree of dysplasia that it presents, 30% local recurrence rate and genetic alteration related to PI3K pathway and PTEN, a tumour suppressor gene. The major portion of the ductal proliferations retains the lobular architecture and is lined by a layer of myoepithelial cells with rare incidence of invasive carcinoma. These features suggest the lesion to be considered a benign process until a rare invasive component or metastases is detected.