Mini Review - (2021) Volume 0, Issue 0
Sclerosing polycystic adenosis or adenoma- the term is open for discussion. The lesion is termed sclerosing polycystic adenosis-a pseudo neoplastic reactive inflammatory process that appears similar to sclerosing adenosis of the breast- in the recent WHO 2017 salivary gland tumour classification. It is categorised under other epithelial lesions as sclerosing polycystic adenosis and considers sclerosing polycystic adenoma as a synonym. The evidence to state the lesion to be a neoplastic process rather than reactive is on the rise and consideration should be given based on the degree of dysplasia that it presents, 30% local recurrence rate and genetic alteration related to PI3K pathway and PTEN, a tumour suppressor gene. The major portion of the ductal proliferations retains the lobular architecture and is lined by a layer of myoepithelial cells with rare incidence of invasive carcinoma. These features suggest the lesion to be considered a benign process until a rare invasive component or metastases is detected.
Sclerosing polycystic adenosis • Sclerosing polycystic adenoma • Apocrine differentiation • Hyalinization • Ductal carcinoma in situ • PI3K pathway • X-chromosome inactivation