Steven Tobochnik, Camilo Gutierrez, Peter Crino and Patrick Connolly
Nonlesional neocortical epilepsy (NLNE) is a challenging problem to treat. Medical management with
antiepileptic drugs (AEDs) frequently fails, and surgical management of refractory epilepsy is often required. With precise electrophysiological localization and resection, seizure reduction and even remission can be achieved. Frequently, lesional tissue is discovered in resected tissue specimens, even when not identified preoperatively by brain MRI. In this review, we describe the diagnostic and surgical approach to patients with NLNE refractory to medical management.