U.Subasini, S.Thenmozhi, V.Venkateswaran, P.Pavani, Sumeet Diwedi, G. Victor Rajamanickam
Hyperlipidemia is the leading cause for the development of various diseases made pharmaceutical companies to turn towards the herbal products with fewer side effects. In the present research, the Hyperlipidemia activity of Nelumbo nucifera Flower (NN) along with their phytochemical evaluation has been done. The Hyperlipidemia effect of hydroalcoholic extract of Nelumbo nucifera Flower was evaluated in Poloxamer 407 induced hyperlipidemic in male Wistar rats. Hyperlipidemia was induced by giving Poloxamer 407 intrapertonial route for 15 days. The groups of rats selected for the study were treated with Atorvastatin, ethanol extract of Nelumbo nucifera (NN). The analysis of lipids profile such as cholesterol, HDL, LDL, VLDL, Triglycerides and liver markers such as SGOT, SGPT were carried out at the end of the study. Administration of NN significantly decreases the Lipid profile and Liver Markers. Likewise, remarkable increase in the level of HDL-C when compared to standard Atorvastatin drug. The levels of SGOT and SGPT were estimated and found to be significantly less than that of hyperlipidemic control group. The results reveal that NN is a rich source for phytoconstituents and can be used as a potent anti Hyperlipidemic agent in pharmaceutical industry.
