Shane Cullen
Covid-19 is a major human infectious disease that has afflicted a number of countries. In the pathophysiology of Covid-19, the cytokine storm plays a key role. The link between inflammation and oxidative stress has been established for a long time. The goal of this study is to evaluate oxidative stress markers in Covid-19 patients to healthy participants.The pandemic of Coronavirus Disease 2019 (Covid-19) has quickly spread over the world, posing a serious threat to global health. This disease was discovered for the first time in Wuhan, China, in December 2019. The pathogenic agent of Covid-19 illness is the severe acute respiratory Syndrome Coronavirus 2 (SARS-CoV-2), an enveloped RNA betacoronavirus. SARSease CoV-2's of transmission is a crucial factor in the virus's widespread dissemination. Covid-19's clinical course might range from asymptomatic to severe symptoms (acute lung injury), 3-4 days in the hospital, transfer to the Intensive Care Unit (ICU), and even death. The Covid-19 problem has drastically increased the probability of negative consequences in recent months. To reduce the risk of hospitalisation and mortality, it is necessary to discover complex pathogenic pathways of disease. Inflammation and cytokine production are frequently associated with respiratory virus infections. Covid-19 sufferers have been shown to have high levels of cytokines and chemokines in their blood. A cytokine storm ensued in certain cases, which is thought to be a critical element in the development of acute respiratory distress syndrome and multiple organ dysfunctions. Oxidative stress plays an important role in inflammatory processes; Reactive Oxygen Species (ROS) and H2O2 can activate NF-B, triggering the generation of inflammatory cytokines. The pathophysiology of SARS-CoV-2 infection is thought to be linked to oxidative stress. In this study, we compared healthy control volunteers to covid-19 patients and assessed oxidative indicators including TOS (total oxidant status), MDA (malondialdehyde), and antioxidant markers like CAT (catalase), SOD (super oxide dismutase).
