Md Moshiur Rahman
Cytokine storm is a term that is applied to response to pathogens causing cytokine discharge. The pathogenesis is mind-boggling however incorporates loss of administrative control of proinflammatory
cytokine creation, both at nearby and fundamental levels. The infection advances quickly, and the mortality is high. Cytokine storm is considered as one of the significant reasons for
acute respiratory distress syndrome (ARDS) and different organ failure.1,2 Some proof shows that, during the coronavirus infection 2019 (COVID-19) period, serious crumbling in certain patients has
been firmly connected with dysregulated and over the top cytokine discharge. In this manner, successfully stifling the cytokine storm is a significant method to forestall the crumbling of patients with COVID-19 disease.3 The COVID-19 pandemic has changed the demonstration of medicine and neurosurgery around the world, as requirements across clinical systems move to oblige a flood in COVID-19 patients. This discussion denotes that we are aware of the pathogenesis and treatment modalities of the COVID-19 infection as well as neurological diseases associated with it, to give some foundation to illuminate future direction for clinical treatment. In some patients, the immune system activation against COVID-19 is massive and creates a hyperactive immune response called cytokine storm. 4 This is applicable to understanding the current COVID-19 flare-up, specifically as it has been accounted for that people who have been freed from COVID-19 contamination. Increase level of pro-inflammatory cytokines & chemokines are present in COVID-19, SARS, and MERS-CoV infection.5 These are mainly IL-1B, IL-6, IL-12, Interferon γ, CXCL 10, CCL 2. Additionally in COVID-19, there are IL-4, IL-10 that can cause immune suppression.6 In COVID-19 patients CD4, CD8, NK T cells are low and monocyte & macrophages are high, which is the explanation of increase levels of these chemicals.
