Parbati Thapa, Rajani Shakya, Balla Ram Malla
Background: Gentamicin (GM) is the mainstay of antimicrobial treatment of infections caused by gram negative bacilli, including intra abdominal and urinary tract infections and diverse hospital acquired infections. Although various side effects have been reported, including ototoxicity and neuromuscular junction blockade, the major drawback of GM
usage is nephrotoxicity. The reported rates of GM nephrotoxicity vary widely from as low as 1.2% up to as high as 55%, although most studies report rates of between 8% and 26%. So the monitoring of SCr, during GM therapy is essential.
Objective: The study aimed to determine the elevation of Serum Creatinine (SCr) from its base line value and to determine the relationship between rise in SCr value with factors such as age and gender in patients during GM therapy .
Methodology: A non-interventional prospective study was conducted in Dhulikhel Hospital, Kathmandu University Teaching Hospital, Dhulikhel, Kavre, Nepal. Outcome of
interest was the rise in SCr value from its baseline value in post surgical patient prescribed with GM. The obtained data were entered in Statistical Package for Social Sciences (SPSS 10) and were analyzed.
Result: A total number of 30 patients were enrolled in the study. Rise in SCr value from baseline was not significant on 3 rd day of GM therapy (P = 0. 257). However there was significant rise in SCr value from baseline after completion of the therapy (P = 0.005). Among 30 patients there were 21(70%) male and 9(30%) female, however gender difference showed no role in rise in SCr value (p=0.576). Significant difference in rise in SCr value was found with advanced age.
Conclusion: A significant rise in SCr value was observed after completion of GM therapy as
compared with baseline SCr value.
