The Relation between the Microbiome and HIV are talked about here. With Recent advances there are parcel of studies behind the sequencing, examination and ID of the huge number of microorganisms containing the human miniature biome. The connection between the Bacteria and Fungi are all around examined in this period as it causes the most perilous and repulsive illnesses as Human Microbes . The quantity of microscopic organisms and parasites genera present in an individual is determined to the quantity of genera present in an uninfected individual and HIV Infected individual. Microbial movement is characterized as the movement of microorganisms as well as microbial items without plain bacteremia, happening after harm to the gastrointestinal lot. This recommends that injury to the invulnerable segment of the gastrointestinal mucosal surface, alongside harm to the intestinal epithelial microenvironment with its antimicrobial capacities, may impact foundational resistant initiation during the persistent period of HIV contamination through the expanded movement of luminal microbial items.