A healthy lifestyle must include both Physical Activity (PA) and nutrition since they can affect energy balance, enhance the functionality of numerous systems, and boost immunity. The most frequent and widespread threats to human health, infections and the symptoms that go along with them, have negative effects on society and the economy all around the world. The severe aging related alterations and dysfunctions of the human immune system are referred to as immunosenescence. Immunosenescence is the clinical term for the ageing immune system that makes people more susceptible to diseases and decreases the effectiveness of vaccines. Such a phenomena is associated with weakened immune responses that result in the failure of numerous organs, while sedentary lifestyles, gradual muscle loss, and concurrent declines in muscular strength promote immunosenescence and inflammation. In this overview, we've spoken about how nutrition and PA can strengthen the immune system both separately and together. There is evidence that long term PA helps the immune system develop and protects against many infections. We've also covered a number of dietary tactics for strengthening the immune system. Sadly, the evidence that is now available yields contradictory findings. Regarding interactions with food consumption, PA does not typically lead to an increase in energy intake over a brief period of time. But it seems that treating nutritional deficits is the most sensible advice. One can meet the biological requirement of adequate nutrition, which has a substantial impact on the immune system, by consuming a balanced, nutritious diet. It's generally not a good idea to take a single nutrient supplement in the form of food. An appropriate nutrient intake may be achieved by substituting different fruits and vegetables, whole grains, proteins, and probiotics. Therefore, persons who are deficient despite eating a decent diet may benefit from multi nutrient supplementation. Supplementing with probiotics, bovine colostrum, plant derived goods, and functional meals may also aid the immune system in addition to PA.