Chronic diseases such as cancer and other non-communicable diseases are fast replacing communicable diseases in India and other developing countries. Tobacco is the most important identified cause of Oral cancer followed by dietary practices, inadequate physical activity, alcohol consumption, infections due to viruses and sexual behavior. Cancer prevention includes primary and secondary prevention measures. Public education on tobacco and its health hazards recommended dietary guidelines, safe sexual practices, and lifestyle modifications form the main features of primary prevention of cancer. Incorporating screening for oral cancers into peripheral health infrastructure can have a significant effect on reducing mortality and form the mainstay for the secondary prevention measure.