A health information system (HIS) is the intersection of between healthcare's business process, and information systems to deliver better healthcare services. The nature of healthcare industry, which is highly influenced by economic, social, politic, and technological factors, has changed over time. This paper will address some important concepts of healthcare and related terminologies to provide a holistic view for HIS. Related technological milestones and major events are briefly summarized. The trends and rapid development of health information technologies are also discussed.