Vijay Nigam
Objective: The study was done on anti hyperglycaemic effect of aqueous extract of the flower of Polygonum orientale Linn. in streptozotocin (STZ) induced diabetic mice.
Methods: Experimental diabetes was induced by single intraperitoneal injection of 55mg/kg of Streptozotocin (STZ) freshly dissolved in distilled water. Control animals received only distilled water. After 48 hrs of Streptozotocin injection animals with fasting blood glucose above 200mg/dl were considered as diabetic and included in the study. The animals were randomly assigned into five groups of six animals Results: The flower extract of Polygonum orientale Linn.in doses 100 and 200 mg/kg b.w was administered for 21 days and blood glucose level, serum cholesterol, liver glycogen was estimated. Treatment of the Streptozotocin induced diabetic mice with the flower extract resulted in significant reduction of blood glucose level (P<.0001), serum cholesterol (P<.01) and increase in liver glycogen (P<.0001).
Conclusion: The results suggest that the flower extract of Polygonum orientale Linn. possess anti hyperglycaemic effect in Streptozotocin induced diabetic mice which justify the traditional use of this plant as ethno-medicine in treatment of diabetes.
