While late-onset Alzheimer's disease Late-Onset Alzheimer's Disease (LOAD) is more common, Early-Onset Alzheimer's Disease (EOAD) with onset before 65 years of age differs significantly from LOAD. EOAD accounts for around 5% of all cases of Alzheimer's disease and is linked to delayed diagnosis, an aggressive course, and age-related psychosocial demands. In addition to cognitive impairments, the phenotypic variations feature atrophy and white matter alterations that match physically to the cognitive changes, and they appear to involve different brain networks than conventional Alzheimer's Disease (AD). The treatment of EOAD is similar to that of LOAD, but more attention should be paid to the specific cognitive regions implicated, as well as more age-appropriate psychosocial support and education. Earlyonset Alzheimer's disease has many of the same symptoms as "late-onset" Alzheimer's disease and is not caused by known genetic abnormalities. Persons in their 30s or 40s can acquire non-familial early-onset AD, but this is exceedingly unusual; most people affected are in their 50s or early 60s. The treatment of EOAD is similar to that of LOAD, but more attention should be paid to the specific cognitive regions implicated, as well as more ageappropriate psychosocial support and education.
