Tissue regeneration is an important process in the skeletal system of humans throughout their lives. The construction of bone structures and teeth is heavily reliant on this continual operation to keep them in good working order. All of the components involved in the fundamental operation of our skeletal system are always in danger of injuries and deformations throughout our lives. As a result, promoting bone and tooth regeneration has become a vital countermeasure in modern medicine to address these acquired abnormalities. There are a variety of approaches to treating erosive disorders of the bone and teeth, but natural chemicals have risen in favor in recent years. These materials offer a wide range of medicinal agents with various biological properties. Based on the source of natural candidates and prospective clinical indications, a complete exploration has been implemented in this study to collect and categorize the relevant scientific information on this problem. The database search yielded a sizable data set, with over 300 references in this field. All of the recommended elements, according to the findings, may be divided into two categories: scaffolding and osteogenesis (or dentinogenesis) induction. A handful of them have therapeutic usefulness that has been established in clinical studies, but for the others, further research is needed before a judgment can be made.
