Journal of Multiple Sclerosis

Abstract

Understanding the molecular basis of Central Nervous System (CNS) demyelination, remyelination, and hypomyelination is crucial for the development of future neuroregenerative therapies given the prevalence of well-known demyelinating disorders like Multiple Sclerosis (MS) and the growing number of pathologies recently found to involve hypomyelinating factors like micronutrient deficits. This review highlights recent research on the role of iron, transferrin, and galectin-3 (Gal-3), as well as their ability to positively influence the development of Oligodendroglial Precursor Cells (OPCs), in the processes of myelination and remyelination. The involvement of glial and Neural Stem Cells (NSC) in the remyelination process was assessed using both in vivo and in vitro assays on primary cell cultures in studies on Cuprizone (CPZ)-induced demyelination and Iron Deficiency (ID)- induced hypomyelination

Keywords

Multiple sclerosis • Microglia • Demyelination • Oligodendrocyte • Galectin-3 • Remyelination