Editorial - (2025) Volume 11, Issue 3
In the relentless battle against leukemia, a groundbreaking treatment has emerged that redefines how we harness the immune system: CAR-T cell therapy. This revolutionary approach doesn’t rely on external drugs to kill cancer—it transforms the patient’s own immune cells into precisionguided cancer assassins. CAR-T stands for Chimeric Antigen Receptor Tcell therapy. It’s a form of cellular immunotherapy where a patient’s T cells—white blood cells that play a central role in immune defense—are genetically modified to recognize and attack cancer cells. The process begins with leukapheresis, a procedure that extracts T cells from the patient’s blood. These cells are then sent to a specialized lab where they’re engineered to express chimeric antigen receptors (CARs) on their surface. These synthetic receptors allow the T cells to identify specific proteins (antigens) found on leukemia cells, such as CD19, a common marker in B-cell leukemias.
Abstract
In the relentless battle against leukemia, a groundbreaking treatment has emerged that redefines how we harness the immune system: CAR-T cell therapy. This revolutionary approach doesn’t rely on external drugs to kill cancer—it transforms the patient’s own immune cells into precisionguided cancer assassins. CAR-T stands for Chimeric Antigen Receptor Tcell therapy. It’s a form of cellular immunotherapy where a patient’s T cells—white blood cells that play a central role in immune defense—are genetically modified to recognize and attack cancer cells. The process begins with leukapheresis, a procedure that extracts T cells from the patient’s blood. These cells are then sent to a specialized lab where they’re engineered to express chimeric antigen receptors (CARs) on their surface. These synthetic receptors allow the T cells to identify specific proteins (antigens) found on leukemia cells, such as CD19, a common marker in B-cell leukemias.
Published: 26-Sep-2025, DOI: 10.35248/2471-8556.25.11(3).013
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