Hemorrhagic
stroke which is a form of
stroke that affects 20% of all
stroke patients is a devastating condition for which new treatments must be developed. Current treatment methods are quite insufficient to reduce long term
morbidity and high mortality rate, up to 50%, associated with bleeding into critical
brain structures, into ventricular spaces and within the subarachnoid space. During the last 10-15 years, significant advances in the understanding of important mechanisms that contribute to cell death and clinical deficits have been made. The most important observations revolve around a key set of basic mechanisms that are altered in
brain bleeding models, a hemorrhage cascade, including activation of membrane metalloproteinases,
oxidative stress and both inflammatory and coagulation pathways. Moreover, it is now becoming apparent that
brain hemorrhage can activate the ischemic cascade in neurons, glial
cells and the vascular compartment. The activation of multiple pathways allows comes the opportunity to intervene pharmacologically using monotherapy or combination therapy. Ultimately, combination therapy or pleiotropic compounds with multi-target activities should prove to be more efficacious than any single therapy alone. This article provides a comprehensive look at possible targets for small molecule intervention as well as some new approaches that result in metabolic down-regulation or inhibition of multiple pathways simultaneously. The top online publishing
journals publish
articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact
factor is a measure reflecting the average number of citations to recent
articles published in the journal. The impact of the journal is influenced by impact factor, the
journals with high impact
factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international
journals are among the best
open access journals in the world, set out to publish the most , relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research
articles but also review
articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact
factor and try to increase their number rapidly. Impact
factor plays a major role for the particular journal.
Relevant Topics in General Science