Oxidative
stress innovations of reactive oxygen
species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of
cells can cause toxic effects through the production of peroxides and
free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative
stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. Base damage is mostly indirect and caused by reactive oxygen
species (ROS) generated, e.g. O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide).Further, some reactive oxidative
species act as cellular messengers in redox signalling. Thus,
oxidative stress can cause disruptions in normal mechanisms of cellular signalling.
Relevant Topics in General Science