Oncology & Cancer Case Reports

Nephropathy is a broad medical term used to denote disease or damage of the kidney, which can eventually result in kidney failure. The primary and most obvious functions of the kidney are to excrete any waste products and to regulate the water and acid-base balance of the body – therefore loss of kidney function is a potentially fatal condition. Nephropathy is considered a progressive illness; in other words, as kidneys become less and less effective over time (with the progression of the disease), the condition of the patient gets worse if left untreated. This is the reason why it is pivotal to receive adequate diagnosis and treatment as early as possible. Diabetic nephropathy is considered a major microvascular complication of diabetes mellitus that affects approximately one-third of all diabetic patients. It usually accompanies albuminuria with glomerular hyperfiltration and renal hypertrophy in the early stage, often showing a deteriorating course that can lead to end-stage renal failure. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. Histopathologically, diabetic nephropathy is characterized by glomerulosclerosis with thickening of the glomerular basement membrane, abnormalities of podocytes (terminally differentiated cells located in the Bowman’s capsule of the kidney) and extracellular matrix accumulation in the glomerular mesangial area.