A genetic disorder is a
health problem caused by one or more abnormalities in the genome. It can be caused by a
mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome. The
mutation responsible can occur spontaneously before embryonic development (a de novo mutation), or it can be inherited from two parents who are carriers of a faulty gene (autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance). Some disorders are caused by a
mutation on the X
chromosome and have X-linked inheritance. Very few disorders are inherited on the Y
chromosome or mitochondrial DNA. There are well over 6,000 known genetic disorders,[4] and new genetic disorders are constantly being described in medical literature.[5] Around 1 in 50 people are affected by a known single-gene disorder, while around 1 in 263 are affected by a chromosomal disorder. Around 65% of people have some kind of
health problem as a result of congenital genetic mutations. Due to the significantly large number of genetic disorders, approximately 1 in 21 people are affected by a genetic disorder classified as "rare" (usually defined as affecting less than 1 in 2,000 people). Most genetic disorders are rare in themselves. Cancers are caused by genetic mutations but are generally omitted when referring to genetic disorders, since most are not hereditary (though predispositions and
cancer syndromes exist).
High Impact List of Articles
-
International Conference on Smart Computing and Communication (SmartTech-2017)
Deepshikha Bhargava, Ramesh C. Poonia, Swapnesh Taterh Editorials: Journal of Biology and Today's World
-
Fatal Event of the Gallbladder Rupture Following the Blunt Abdominal Trauma: A Case Report
Roya Kordrostami, Maryam Ameri, Nahid Dadashzade, Tayeb Ramim, Case Reports: Journal of Biology and Today's World
-
A study on effect of training communication skills on knowledge and attitudes of family phy-sicians and patients satisfaction
Zohreh Naghavi,Khatere Anbari,Azita Zafar,Mohammad Ali Derik Research Article: Journal of Biology and Today's World
-
"Combined effect of mild heat and zinc oxide nanoparticle treatment for inactivating Escherichia coli, Listeria Monocytogenes and Staphylococcus aureus in milk"
Mahboubeh Mirhosseini1, Narjes Mohammadi, Maryam Shirzad Research Article: Journal of Biology and Today's World
-
"Comparison of the Outcomes of Traditional and Misgav-Ladach Techniques in Caesarean Section"
Anisodowleh Nankali, Farin Farajzadeh, Mansour Rezaei, Shohreh Malekkhosravi, Sara Daeichin Research Article: Journal of Biology and Today's World
Relevant Topics in Medical Sciences