A DNA microarray technology utilizes the collection of microscopic DNA spots attached to a solid surface. DNA microarrays are used to estimate the expression levels of large numbers of genes at the same time or to genotype different regions of a genome. It is a tool used to determine whether the DNA from a particular individual contains a
mutation in genes like BRCA1 and BRCA2. The chip consists of a small glass plate encased in plastic. Some companies manufacture microarrays using methods similar to those used to make computer microchips. The DNA copy that is made, called complementary DNA (c DNA), is then applied to the microarray. The c DNA binds to complementary base pairs in each of the spots on the array, a process known as hybridization. A black spot indicates that none of the patient's c DNA has bonded to the DNA in the gene located in that spot. Microarray technology is a powerful technique used to compare differences in
gene expression between two mRNA samples. Comparing RNA prepared from diseased
cells and normal
cells can lead to the identification of sets of genes that play key roles in diseases.
High Impact List of Articles
-
The effect of Pomegranate juice, Date palm and Fig fruit in treatment and prevention of experimental acute colitis model on rat: Immunopathogenesis aspect
Farideh Zafari-Zangeneh, Mohammad Mehdi Naghizadeh, Fatemeh Amini Research Article: Journal of Biology and Today's World
-
"Factors Related in Mammography Screening Adoption: an Application of Extended Parallel Process Model"
Elaheh Vatannavaz, Parvaneh Taymoori Research Article: Journal of Biology and Today's World
-
"Needle - Stick and Medication Errors due to their Job Stress Emergency by Nurses- a Descriptive Study in Kermanshah Hospitals, Iran"
Mehdi Mirzaei-Alavijeh, Farzad Jalilian, Behzad Karami-Matin, Arsalan Ghaderi, Mohammad Mahboubi, Razieh
Janizadeh, Fatemeh Hidarpour, Amineh Khodadadi Short Communication: Journal of Biology and Today's World
-
The Validity of Euro Score in Patients who underwent off pump coronary artery bypass graft
Mehdi Hadadzade, Seyed Khalil Forouzania, Seyed Jalil Mirhoseini, Hamide Peighambari, Naeeme Naserzade, Ali Akbar Rahimianfar Research Article: Journal of Biology and Today's World
-
Study of the Effect of Intra-abdominal Lidocaine on Postoperative Abdominal and Scapular Pain in Elective Laparoscopic Cholecys-tectomy Candidates
"Habibollah Hosseini, Arezoo samaei, Mohammad Zare, Mohammad Hassan Abdollahi, Ali Akbar
Rahimianfar, Mohammad Dehghan-Tezerjani Research Article: Journal of Biology and Today's World
Relevant Topics in Medical Sciences