Dermatomyositis is a tissue related disorder which results in the inflammation of connective tissues, muscles, and skin. The top
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Dermatomyositis (DM) is a chronic inflammatory disorder of the
skin and muscles. Evidence supports that DM is an immune-mediated disease and 50–70% of patients have circulating myositis-specific auto-antibodies. Gene expression microarrays have demonstrated upregulation of
interferon signaling in the muscle, blood, and
skin of DM patients. Patients with classic DM typically present with symmetric, proximal muscle weakness, and
skin lesions that demonstrate interface dermatitis on histopathology. Evaluation for muscle inflammation can include muscle enzymes, electromyogram,
magnetic resonance imaging, and/or muscle biopsy.
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