Oncology & Cancer Case Reports

ISSN - 2471-8556

Cancer Epigenetics

Epigenetic mechanisms are essential for mundane development and maintenance of tissue-categorical gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Ecumenical transmutations in the epigenetic landscape are a hallmark of cancer. The initiation and progression of cancer, traditionally optically discerned as a genetic disease, is now realized to involve epigenetic abnormalities along with genetic alterations. Recent advancements in the expeditiously evolving field of cancer epigenetics have shown extensive reprogramming of every component of the epigenetic machinery in cancer including DNA methylation, histone modifications, nucleosome situating and non-coding RNAs, categorically microRNA expression. The intricacy of cancer biology can be explicated as the interplay between genetic and epigenetic abnormalities that are mutually salutary in order to drive cancer initiation and progression. The consequentiality of epigenetic alterations as driving forces of tumor initiation limpidly emerged from studies of pediatric cancers, especially encephalon tumors, which are characterized by few or no recurrent mutations, and are instead defined by their aberrant epigenetic patterns. These molecular alterations lead to perpetual transmutations in the patterns of gene expression that regulate the neoplastic phenotype, such as cellular magnification and invasiveness. In this component of the present review, we fixate on recent revelations of epigenetic alterations in several types of tumors including breast, prostate, lung and colon cancer. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects.

Relevant Topics in Medical Sciences

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