Epigenetic mechanisms are essential for mundane development and maintenance of tissue-categorical
gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Ecumenical transmutations in the epigenetic landscape are a hallmark of cancer. The initiation and progression of cancer, traditionally optically discerned as a genetic disease, is now realized to involve epigenetic abnormalities along with genetic alterations. Recent advancements in the expeditiously evolving field of
cancer epigenetics have shown extensive reprogramming of every component of the epigenetic machinery in
cancer including DNA methylation, histone modifications, nucleosome situating and non-coding RNAs, categorically microRNA expression. The intricacy of
cancer biology can be explicated as the interplay between genetic and epigenetic abnormalities that are mutually salutary in order to drive
cancer initiation and progression. The consequentiality of epigenetic alterations as driving forces of
tumor initiation limpidly emerged from studies of pediatric cancers, especially encephalon tumors, which are characterized by few or no recurrent mutations, and are instead defined by their aberrant epigenetic patterns. These molecular alterations lead to perpetual transmutations in the patterns of
gene expression that regulate the neoplastic phenotype, such as cellular magnification and invasiveness. In this component of the present review, we fixate on recent revelations of epigenetic alterations in several types of tumors including breast, prostate, lung and colon cancer. The top online publishing
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