There is an increasing need for second-line therapy in resource-limited settings in sub-Saharan African countries. We sought to describe the one-year incidence of loss to follow up and mortality among patients taking second line ART at an experienced ART program in southwestern Uganda.A retrospective cohort study was conducted at Mbarara Regional Referral Hospital mHIV clinic among adults who started second line ART between 2002 and 2017. We assessed social-demographic, clinical and laboratory variables routinely collected at the initiation of msecond line ART. Variables that had a p<0.05 in unadjusted bivariate analyses were included into a multivariate binomial regression model using a step wise backward selection procedure to describe the factors that independently predicted loss to follow up and mortality at p<0.05
