ALS and other efferent neuron diseases are specified by steady, unabated, escalating degeneration of corticospinal tracts, anterior horn cells and bulbar motor nuclei. Symptoms vary in extremity and should include muscle weakness and atrophy, fasciculations, emotional lability and respiratory muscle weakness. ALS, or amyotrophic lateral sclerosis, may be a progressive neurodegenerative disease that affects motor neurons. there's no cure for ALS. Although ALS may be a brain disorder closely associated with Parkinson's, Alzheimer's, and Huntington's diseases, thus far the complex descriptions of ALS-associated damage haven't clarified the last word causative mechanisms. Current interventions are the results of unintentional discoveries or the non-specific application of cell-based therapies whose effects aren't completely understood. However, research on ALS is currently thriving and therefore the body of data on the topic has increased remarkably in recent years. The emergence of functional immunomics for ALS from established omics technologies are opening new therapeutic avenues supported the smart manipulation of the system . Molecular imaging within the field of ALS is evolving. Thus, a mixture of omics technologies and clinical imaging may alright be the key for breaking-down ALS.