Aging is the progressive accumulation of damage to an organism over time leading to disease and death.
Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of
aging and finding possibilities to fight age-related diseases. Various theories of
aging have been proposed. In the last years
advanced glycation end products (AGEs) have received particular attention in this context. AGEs are formed in high amounts in
diabetes but also in the physiological organism during aging. They have been etiologically implicated in numerous diabetes- and age-related diseases. Strategies inhibiting AGE accumulation and signaling seem to possess a therapeutic potential in these pathologies. However, still little is known on the precise role of AGEs during
skin aging. In this review the existing literature on AGEs and
skin aging will be reviewed. In addition, existing and potential anti-AGE strategies that may be beneficial on
skin aging will be discussed
Relevant Topics in General Science
