Department of Pedodontist and Preventive, Private Practitioner, India
Case Report
Diabetes and Periodontal Disease: The Reciprocal Relationship
Author(s): Sharayu Dhande*, Mariam Khan, Sangeeta Muglikar, Sagar Chaudhari, Sheetal Ajit Jangale and Ajit Govind Jangale
Diabetes is a metabolic disorder whereas Periodontal disease is an infectious disease, the bi-directional relationship between them occurs through the ability of both conditions to induce an inflammatory response leading to overproduction of pro-inflammatory mediators. On the other hand, inflammation is known to cause increased insulin resistance. These pro-inflammatory cytokines such as IL-6, TNF-α, are known to impair the glucose-stimulated release of insulin from the pancreas, resulting in to increase in sugar levels. As a result, Periodontal disease has also been considered as the 6th complication of diabetes mellitus. In prolonged hyperglycemic states, advanced glycation end products form which crosslinks with collagen, making it less soluble, less likely to be replaced, and more susceptible to breakdown. A combination of genes could also result, in a host who, under the in.. View More»
