Journal of Pharmaceutical Sciences and Drug Development

Pseudomonas aeruginosa in Industries

Nida Tabassum Khan^{* *}Correspondence: Nida Tabassum Khan, Department of Biotechnology, Faculty of Life Sciences & Informatics, Baluchistan University of Infor, Engineering and Management Sciences, Takatu Campus, Airport Road, Quetta, Baluchistan, Pakistan, Email:

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Introduction

A monoflagellated gram-negative rod-shaped bacterium that is known to human as an opportunistic pathogen [1]. Pseudomonas aeruginosa is of great clinical significance since it is a multidrug resistant microbe perceived for its presence in any sort of environment [2]. Pseudomonas aeruginosa rhamnolipids, glycolipidic surface-dynamic molecules which have potential biotechnological applications [3, 4]. Rhamnolipids are produced by Pseudomonas aeruginosa in biosynthetic pathway and exhibits metabolic connections with various bacterial secretes including alginate, lipopolysaccharide, polyhydroxyalkanoates, and 4-Hydroxy2-Alkylquinolines (HAQs) [5, 6]. Pseudomonas aeruginosa secretes an exopolysaccharide called alginate that provide protection to the microbes in difficult environmental conditions and furthermore improves its adhesion to strong surfaces [7, 8]. Alginate biosynthetic gene is incited upon connection to the base surface and this prompt expanded alginate synthesis [9]. Subsequently, biofilms which are beneficial to the endurance and development of the microorganisms is formed [10, 11]. Moreover, versatile anti-toxin resistance of Pseudomonas aeruginosa incorporates biofilm-interceded resistance and development of multidrugtolerant persistent cells for recalcitrance and relapse of infections [12, 13]. Pseudomonas aeruginosa plays an important in biotechnology-based applications some of which are as follows:

It is broadly utilized as a model organism because of its wide metabolic adaptability that it is generally used to study biotechnological applications [14].

Pseudomonas aeruginosa is utilized for the investigation of antibiotic resistance and pathogenesis [15]. It produces an enormous number of compounds with bacteriostatic or bacteriocidic properties, these compounds are significant in the control of various Multi Drug Resistance (MDR) [16, 17]. For example, carbapenems producing Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus [18].

• Pseudomonas aeruginosa plays a significant role in the bioremediation of heavy metals like lead, copper, cadmium and chromium since metals are straightforwardly and by implication engaged with all parts of microbial development [19]. Different Pseudomonas aeruginosa strains can biodegrade countless toxic compounds that are recalcitrant to other bacterial species, subsequently delivering auxiliary metabolites and biopolymers, making these strains helpful in medication and industries [20, 21].

• Pseudomonas aeruginosa has valuable purposes in different modern applications and industrial sectors as these bacteria incorporates the ability to biodegrade waste, petroleum processing derived from plants, agribusiness, mash and paper, mining etc. [22, 23]. They can also be used in commercial and household drain cleaners and degreasers, septic tank additives, general cleaning products, and odour control products [24, 25].

• Various strain of Pseudomonas aeruginosa has been recognized as micro factories for the biosynthesis of useful substances [26]. Some of these products are given below:

• Vanillin: Recent studies reported that Pseudomonas aeruginosa ISPC2 strain produces vanillin through microbial biotransformation utilizing isoeugenol as a precursor molecule [27].

• Rhamnolipids: It has been shown that rhamnolipids can be investigated to control and disrupt the formation of bacterial biofilms mainly of food-borne microbes [28].

• Protease: Proteolytic enzymes are to a great extent tracked down in every single living creature and are vital for the development of cells [29]. Pseudomonas aeruginosa releases extracellular protease utilizing maltose as a significant carbon source [30].

• Lipase: Pseudomonas aeruginosa are one of the most amazing producers of lipase catalyst which have shown extraordinary potential concerning their application in various industrial enterprises [31].

• Biopigments: The different kinds of pigments produced by Pseudomonas aeruginosa are to a great extent classed under the synthetic name of phenazines [32]. Phenazine compounds are of good biotechnological value [33].

Conclusion

Thus, Pseudomonas aeruginosa have been widely implicated as clinical pathogens but it is also offering numerous biotechnological benefits.

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