Rohan R. Narkhede, Rahul D, Ashwini V. Pise, Pramod Kumar, Indrajeet Singh, Somnath Kalegaonkar
The atherosclerosis is characterized by elevated levels of cholesterol. The underlined cause of most of the coronary cardiovascular diseases is elevated lipid level also known as hyperlipidemia. There are some synthetic antihyperlipidemc drugs are available in market but the exhibit numerous of adverse effect which are undesired. Currently, lots of efforts have been made for development of herbal formulation which exhibit lesser side effect compared to synthetic drugs. The objective of this work is to evaluate the phytoconstituent profile and antihyperlipidemic activity of allium sativum on rat fed with fat rich diet. The phytochemical analysis was carried out by performing the various test established in literature. The activity was evaluated by determining triglycerides, cholesterol and HDL-cholesterol of rats treated with standard and test substance. The phytochemical screening of garlic extract revealed the presence of saponin, terpenoid, flavonoids, volatile oil, amino acid and protein and cardiac glycosides. The extract is found to exhibit antihyperlipidemic activity at dose of 200 mg/kg. The significant drop in levels of total cholesterol triglycrides and HDLcholesterol was observed. Thus this work demonstrated that the extract of Allium sativum has antihyperlipidemic effect on rat fed with fat rich diet.
