Secondary hyperparathyroidism and elevated blood levels of parathyroid hormone (PTH) may play an important role in the pathogenesis of the triglyceridemia of chronic renal failure. A cross-sectional study was carried out at El Minia university hospital dialysis unit. In our study, 189 patients on dialysis and 50 healthy individuals have been included in our study, all of them subjected to full history taking, clinical examination, lipid profile analysis, bone mineral parameters analysis (Ca+2, ph+4, PTH, Alp). They were classified into three groups: Group I: Includes 105 patients on dialysis their parathyroid hormone level less than 300 pg/ml, Group II: Includes 84 patients on dialysis their parathyroid hormone level more than 300 pg/ml, Group III: Includes 50 healthy individuals, as a control group. We found that there is highly significant statistical difference between triglycerides level of patients on dialysis and control group (p<0.001) and highly significant statistical difference between both groups as regard total cholesterol level(p<0.001), while comparison of LDL and HDL levels between control group and patient on dialysis showed no significant statistical difference There is significant positive correlation between parathyroid hormone level and triglyceride level in patients of group I (r=0.438, p=0.029), and between parathyroid hormone level and triglyceride level in patients of group II (r=0.719, p<0.001). The hyperparathyroidism in haemodialysis patients has an essential role in pathogenesis of premature atherosclerosis in these patients.